5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester

Base Information

• Chemical Name: 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester
• CAS No.: 107408-50-4
• Molecular Formula: C₃₇H₄₀BrO₃P
• Molecular Weight: 643.601

Synonyms:5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester

Chemical Property of 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester

Chemical Property:

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Technology Process of 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester

There total 7 articles about 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

n-butyllithium (109-72-8,29786-93-4) + ethyl 7-(2-bromophenyl)-3-oxo-2-(triphenylphosphoranylidine)-4(E)-heptenoate (107408-17-3) → 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ5-phosphanylidene)-nonanoic acid ethyl ester (107408-50-4)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.05h;

Reference yield:

diethyl 2-(2-bromobenzyl)propan-1,3-dioate (66192-11-8) → 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ5-phosphanylidene)-nonanoic acid ethyl ester (107408-50-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 85percent aq. KOH / 2 h / 90 - 100 °C

2: 130 - 195 °C

3: 65 percent / BH₃ / tetrahydrofuran / 1 h / 25 °C

4: 66 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 25 °C

5: 91 percent / NaH / tetrahydrofuran

6: 77 percent / tetrahydrofuran / 0.05 h / -78 °C

With potassium hydroxide; borane; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

Reference yield:

3-(2-bromophenyl)propionic acid (15115-58-9) → 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ5-phosphanylidene)-nonanoic acid ethyl ester (107408-50-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / BH₃ / tetrahydrofuran / 1 h / 25 °C

2: 66 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 25 °C

3: 91 percent / NaH / tetrahydrofuran

4: 77 percent / tetrahydrofuran / 0.05 h / -78 °C

With borane; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

n-butyllithium

ethyl 7-(2-bromophenyl)-3-oxo-2-(triphenylphosphoranylidine)-4(E)-heptenoate

diethyl 2-(2-bromobenzyl)propan-1,3-dioate

3-(2-bromophenyl)propionic acid

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