66192-11-8

Upstream product

• 105-53-3 diethyl malonate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 93098-67-0 diethyl <(2-bromophenyl)methylene>propanedioate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 95-46-5 2-methylphenyl bromide 
• 109-89-7 diethylamine 

Downstream Products

• 66192-12-9 diethyl 2-(2-bromobenzyl)-2-methylmalonate 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 58380-12-4 <(2-bromophenyl)methyl>propanedicarboxylic acid 
• 127619-94-7 Diethyl 2-<(2-bromophenyl)methyl>-2-<3-(trimethylsilyl)-2-propynyl>propanedioate 
• 127619-93-6 Diethyl 2-<(2-bromophenyl)methyl>-2-(2-butynyl)propanedioate 
• 67130-96-5 4-(2-bromophenyl)-2-butanol 
• 3506-68-1 4-(2-bromophenyl)-2-butanone 
• 107408-16-2 3-(o-bromophenyl)propanal 
• 107408-53-7 5-Methylene-3-oxo-7-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-heptanoic acid ethyl ester 
• 107408-17-3 ethyl 7-(2-bromophenyl)-3-oxo-2-(triphenylphosphoranylidine)-4(E)-heptenoate 
• 107408-52-6 4-(1-Methyl-indan-1-yl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester 
• 107408-51-5 ethyl 3-oxo-5-(2-phenylethyl)-2-(triphenylphosphoranylidene)nonanoate 
• 107408-50-4 5-[2-(2-Bromo-phenyl)-ethyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-nonanoic acid ethyl ester 
• 107408-15-1 (Z)-7-(2-Bromo-phenyl)-5-methyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-hept-4-enoic acid ethyl ester 

Relevant academic research and scientific papers

Light-Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII-Aryl Complex

A highly effective C?O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcohols is reported. Catalyzed by a NiII-aryl complex under long-wave UV (390–395 nm) irradiation in the presence of a soluble amine base without any additional photosensitizer, the reaction enables the etherification of aryl bromides and aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcohols, affording synthetically important ethers. Intramolecular C?O coupling is also possible. The reaction appears to proceed via a NiI–NiIII catalytic cycle.

Biocatalytic Desymmetrization of Prochiral 3-Aryl and 3-Arylmethyl Glutaramides: Different Remote Substituent Effect on Catalytic Efficiency and Enantioselectivity

Catalyzed by an amidase-containing Rhodococcus erythropolis AJ270 microbial whole cell catalyst in neutral phosphate buffer at 30 °C, desymmetric hydrolysis of a series of prochiral 3-aryl and 3-arylmethylglutaramides efficiently afforded 3-substituted glutaric acid monoamides in up to 95% yield and >99.5% ee. Even far away from the reaction site, the substituents on the aryl still have a significant effect on the catalytic activity and enantioselectivity and different remote substituent effect was observed for the two types of substrates. The synthetic application of biocatalytic desymmetrization was demonstrated by the facile transformation of the obtained enantiopure (R)-3-substituted 4-carbamoylbutanoic acid products to chiral dihydroquinolinone and δ-lactone compounds. (Figure presented.).

Pd-catalyzed desymmetric intramolecular O-arylation reaction: Enantioselective synthesis of (3,4-dihydro-2H-chromen-3-yl)methanols

An enantioselective intramolecular O-arylation was achieved through desymmetrization with Pd-catalyzed coupling reactions. The intramolecular asymmetric aryl C-O coupling reactions of 2-(2-haloaryl)propane-1,3-diols led to the enantioselective formation o

Ion channel modulating agents

The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

Catalytic generation and trapping of acylmetals containing Ni and Cu with enolates

Carbonylative cyclization of iodoarenes and iodoalkenes containing a proximal enolate precursor can selectively provide either cyclic ketones or lactones in the presence of Ni or Cu catalysts via trapping of putative acylmetal derivatives with C- or O-enolates, respectively; the ring size and regioselectivity of the reaction may be predicted based on two generalizations derived from the recently developed corresponding Pd-catalyzed reaction.

Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors

The design and preparation of ortho-substituted benzofused macrocyclic lactams are described. The benzofused macrocyclic lactams were designed as neutral endopeptidase 24.11 (NEP) inhibitors. Docking studies were carried out in a model of thermolysin (TLN) using the MACROMODEL and QXP modeling programs to select suitable ring sizes. These studies predicted that the 11- , 12-, and 13-membered ring macrocyclic lactams would be active in both enzymes TLN and NEP. Good predictability of experimental results, within this series, of binding to thermolysin and to a lesser extent to NEP was observed. A visual comparison, docked at the active site of TLN, is presented for thiorphan, a 10-membered ring macrocycle and an 11-membered ring benzofused macrocyclic lactam. Potent inhibition of both NEP and thermolysin was obtained. The 11-membered ring macrocycle 25a is the most potent inhibitor from this series of compounds (TLN IC50 = 68 nM; NEP IC50 = 0.9 nM). The effects of prodrug 44b administered at 10 mg/kg po on plasma atrial natriuretic peptide (ANP) levels in conscious rats was greater than 200% over a 4 h period.

Lithium-Halogen Exchange-Initiated Cyclization Reactions. 3. Intramolecular Conjugate Addition Reactions of Unsaturated Acylphosphoranes

The lithium-halogen exchange-initiated intramolecular conjugate addition reactions of some model unsaturated acylphosphoranes have been examined.The effects of halide type, chain length, and acceptor substitution pattern on the feasibility of ring construction were studied.The lithium-bromine exchange reactions in two 2-bromooaryl acceptors were found to be too slow, relative to competing side reactions, to allow practical carbocycle syntheses while 3-,4-,5-, and 6-membered carbocycles are formed in good to excellent yields from precursors that are vinyl and saturated primary iodides.Highly efficient intramolecular conjugate addition reactions to β,β-disubstituted acceptor units are possible, and intermediate anions from intramolecular conjugate addition reactions are readily captured with electrophiles.

Arachidonic acid analogues, processes for their preparation and their use in medicine

A compound of formula (I): STR1 or a salt thereof, in which Y is a group--O(CH2)m CH2)m CH1 and R2, which may be the same or different, represents hydrogen or C1-6 alkyl, X represents a double or triple bond, and each of A and B represents hydrogen when X is a double bond, or both A and B are absent when X is a triple bond, is useful in treating allergic diseases.

Synthesis of Biological Markers in Fossil Fuels. 2. Synthesis and 13C NMR Studies of Substituted Indans and Tetralins

Unambiguous syntheses of all possible methyl, ethyl, n-propyl, and n-butyl derivatives of indan and tetralin were developed using the Kumada coupling procedure involving the reaction of aryl or vinyl halides with Grignard reagents in the presence of nickel(II) chloride.An analysis of the 13C NMR spectra of these compounds was also completed.