(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

Base Information

• Chemical Name: (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide
• CAS No.: 1404054-26-7
• Molecular Formula: Br*C₂₇H₂₇F₂N₂O₃S
• Molecular Weight: 577.49
• Mol file: 1404054-26-7.mol

Synonyms:(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

Chemical Property of (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

There total 3 articles about (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-thiophen-3-yl-ethanone (1468-82-2) + (R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate (1404054-16-5) → (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide (1404054-26-7)

Guidance literature:

In ethyl acetate; at 20 ℃;

Reference yield:

(3R)-quinuclidin-3-amine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide (1404054-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; methanol / 1 h / 20 °C

1.2: 7 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 48 h / 20 °C

3.1: ethyl acetate / 20 °C

With sodium hydride; sodium hydrogencarbonate; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

C11H16N4O → (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide (1404054-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 48 h / 20 °C

2.1: ethyl acetate / 20 °C

With sodium hydride; In ethyl acetate; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

(3R)-quinuclidin-3-amine dihydrochloride

2-bromo-1-thiophen-3-yl-ethanone

(R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate