(E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate
CAS No.:1073314-04-1
Molecular Formula:C₁₆H₁₃FN₄O₂S
Molecular Weight:344.369
Hs Code.:

Synonyms:(E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

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Chemical Property of (E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

Chemical Property:

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Technology Process of (E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

There total 3 articles about (E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073314-01-8
(E)-methyl 3-(5-(4-fluorophenyl)-3-(1H-tetrazol-5-yl)thiophen-2-yl)acrylate

: 74-88-4
methyl iodide

: 1073314-04-1
(E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

: 1073314-03-0
(E)-methyl 3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1073314-04-1
(E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 60 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: N,N-dimethyl-formamide / 4 h / 150 °C

4.1: sodium azide; zinc dibromide / 6 h / 100 °C

5.1: tetrahydrofuran / 5 h / Heating / reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; sodium azide; potassium carbonate; zinc dibromide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 5.1: Wittig Reaction;

Reference yield:

: 1073314-00-7
5-(4-fluorophenyl)-3-(1H-tetrazol-5-yl)thiophene-2-carbaldehyde

: 1073314-04-1
(E)-methyl 3-(5-(4-fluorophenyl)-3-(1-methyl-1H-tetrazol-5-yl)thiophen-2-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / Heating / reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Wittig Reaction;