Chemical Property of Cucurbitacin B
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:1.3E-22mmHg at 25°C
- Melting Point:184-186oC
- Refractive Index:1.568
- Boiling Point:699.3 °C at 760 mmHg
- PKA:12.60±0.29(Predicted)
- Flash Point:218.7 °C
- PSA：138.20000
- Density:1.23 g/cm3
- LogP:3.49930
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:2.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:6
- Exact Mass:558.31926842
- Heavy Atom Count:40
- Complexity:1210
- Purity/Quality:
-
99% *data from raw suppliers
Cucurbitacin B *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Plant Toxins
- Canonical SMILES:CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)C)C)C)O)O
- Isomeric SMILES:CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)C)O)O
-
Description
Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.
-
Uses
Cucurbitacin B hydrate has been used: as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.to determine its effect on the cell viability of pancreatic cancer cell lines.
