(2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

Base Information

Chemical Name:(2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol
CAS No.:906448-60-0
Molecular Formula:C₁₀H₁₃N₃O₃
Molecular Weight:223.232
Hs Code.:

Synonyms:(2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

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Chemical Property of (2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

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Technology Process of (2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

There total 5 articles about (2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 906448-59-7
(2S)-2[(R)-azido(4-methoxyphenyl)methyl]oxirane

: 906448-60-0
(2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

Guidance literature:: With sodium hydroxide; In water; tert-butyl alcohol; at 75 ℃; for 8h;
DOI:10.1080/00397910600619499

Reference yield: 48.0%

: 2-(azido-4-methoxyphenyl-methyl)oxirane

: 906448-60-0
(2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

: 1239893-03-8
(2R,3S)-2-(azido-4-methoxyphenyl-methyl)oxirane

Guidance literature:: With (R,R)-Jacobsen catalyst; water; In tetrahydrofuran; at 0 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c0cc00650e

Reference yield:

: 906448-57-5
(S)-(4-methoxyphenyl)[(2R)-oxiran-2-yl]methanol

: 906448-60-0
(2S,3R)-3-azido-3-(4-methoxyphenyl)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / PPh₃; diisopropyl azodicarboxylate; anhydrous hydrazoic acid / benzene / 1 h / 20 °C

2: 92 percent / NaOH / 2-methyl-propan-2-ol; H₂O / 8 h / 75 °C

With sodium hydroxide; hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine; In water; tert-butyl alcohol; benzene; 1: Mitsunobu reaction;
DOI:10.1080/00397910600619499