(2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

Base Information

Chemical Name:(2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)
CAS No.:916446-61-2
Molecular Formula:C₄₂H₄₄N₄O₄
Molecular Weight:668.836
Hs Code.:

Synonyms:(2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

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Chemical Property of (2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

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Technology Process of (2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

There total 6 articles about (2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: (2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))dipyrrolidine-2-carboxamide dihydrochloride

: 612-19-1
2-ethylbenzoic acid

: 916446-61-2
(2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm301796k

Reference yield:

: (2S,2'S)-tert-butyl 2,2'-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate

: 612-19-1
2-ethylbenzoic acid

: 916446-61-2
(2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

Guidance literature:: (2S,2'S)-tert-butyl 2,2'-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 20 ℃;

2-ethylbenzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.08.049

Reference yield:

: 7314-06-9
(E)-4,4'-diaminostilbene

: 916446-61-2
(2S,2'S)-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(1-(2-ethylbenzoyl)pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 0 - 20 °C

2.2: 20 °C

With hydrogenchloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.08.049