2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Base Information

Chemical Name:2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester
CAS No.:142929-96-2
Molecular Formula:C₃₆H₄₀F₃N₃O₃S
Molecular Weight:651.793
Hs Code.:

2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Synonyms:2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

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Chemical Property of 2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

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Technology Process of 2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

There total 4 articles about 2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 142929-96-2
2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / piperidiene, acetic acid / benzene / 1 h / Heating

2: 41 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

3: 1.) NaH / 1.) DMF, 70 deg C, 30 min., 2.) DMF, RT, overnight

With piperidine; sodium acetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00095a023

Reference yield:

: 25985-08-4
2-(4-methoxybenzyl)isothiourea hydrochloride

: 142929-96-2
2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

2: 1.) NaH / 1.) DMF, 70 deg C, 30 min., 2.) DMF, RT, overnight

With sodium acetate; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00095a023

Reference yield:

: 3-Oxo-2-[1-(2-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-butyric acid 1-benzyl-piperidin-4-yl ester

: 142929-96-2
2-(4-Methoxy-benzylsulfanyl)-4-methyl-1-propyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

2: 1.) NaH / 1.) DMF, 70 deg C, 30 min., 2.) DMF, RT, overnight

With sodium acetate; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00095a023