2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Base Information

Chemical Name:2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester
CAS No.:142946-43-8
Molecular Formula:C₃₃H₃₄F₃N₃O₃S
Molecular Weight:609.712
Hs Code.:

Synonyms:2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

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Chemical Property of 2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

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Technology Process of 2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

There total 2 articles about 2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 25985-08-4
2-(4-methoxybenzyl)isothiourea hydrochloride

: 3-Oxo-2-[1-(2-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-butyric acid 1-benzyl-piperidin-4-yl ester

: 142946-43-8
2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Guidance literature:: With sodium acetate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;
DOI:10.1021/jm00095a023

Reference yield:

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 142946-43-8
2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / piperidiene, acetic acid / benzene / 1 h / Heating

2: 41 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

With piperidine; sodium acetate; acetic acid; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00095a023

Reference yield:

: 142946-43-8
2-(4-Methoxy-benzylsulfanyl)-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-yl ester

: 1,2,3,6-tetrahydro-4-methyl-1-propyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid, 1-(phenylmethyl)-4-piperidinyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 70 deg C, 30 min., 2.) DMF, RT, overnight

2: 33 percent / TFA, ethanethiol / CH₂Cl₂ / Ambient temperature

With sodium hydride; trifluoroacetic acid; ethanethiol; In dichloromethane;
DOI:10.1021/jm00095a023