{1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

Base Information

Chemical Name:{1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol
CAS No.:1012104-60-7
Molecular Formula:C₂₉H₃₁N₅O₂
Molecular Weight:481.597
Hs Code.:

Synonyms:{1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

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Chemical Property of {1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

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Technology Process of {1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

There total 10 articles about {1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012104-61-8
(1-cyclohexyl-2-(5-(3-(methoxymethyl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol

: 1012104-60-7
{1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

Guidance literature:: With hydrogenchloride; In ethanol; water; for 1.5h; Reflux;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1012104-60-7
{1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 5 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride / ethanol; water / 1.5 h / Reflux

With hydrogenchloride; potassium phosphate; iodine; sodium hydride; sodium carbonate; potassium hydroxide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 347174-05-4
3-Amino-4-cyclohexylamino benzoic acid ethyl ester

: 1012104-60-7
{1-cyclohexyl-2-[5-(3-methoxymethylphenyl)-1H-indazol-3-ylamino]-1H-benzo[d]imidazol-5-yl}methanol

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile; ethanol; water / 3.75 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

3: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 5 h / 140 °C / Inert atmosphere; Microwave irradiation

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation

5: hydrogenchloride / ethanol; water / 1.5 h / Reflux

With hydrogenchloride; potassium phosphate; lithium aluminium tetrahydride; sodium carbonate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;