4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide

Base Information

• Chemical Name: 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide
• CAS No.: 76575-42-3
• Molecular Formula: C₁₈H₁₁N₇O₂S
• Molecular Weight: 389.397
• Mol file: 76575-42-3.mol

Synonyms:4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide

Chemical Property of 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide

There total 3 articles about 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-amino-1H-tetrazole monohydrate (15454-54-3) + 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid (76575-34-3) + 1,1'-carbonyldiimidazole (530-62-1) → 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide (76575-42-3)

Guidance literature:

With chloro-trimethyl-silane; triethylamine; In N-methyl-acetamide; acetic acid;

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide (76575-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.5 h / 165 °C

2: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) DMF, 105 deg C, 90 min, 2.) DMF, 105 deg C, 135 min

With 1,1'-carbonyldiimidazole;

DOI:10.1021/jm00139a021

Reference yield:

2-amino-5-phenylthiophene-3-carboxylic acid methyl ester (61325-02-8) → 4-oxo-2-phenyl-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxamide (76575-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.5 h / 165 °C

2: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) DMF, 105 deg C, 90 min, 2.) DMF, 105 deg C, 135 min

With 1,1'-carbonyldiimidazole;

DOI:10.1021/jm00139a021

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

2-amino-5-phenylthiophene-3-carboxylic acid methyl ester

5-amino-1H-tetrazole monohydrate

4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid