61325-02-8

Basic information

• Product Name: METHYL 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOXYLATE
• Synonyms: METHYL 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOXYLATE;2-Amino-5-phenylthiophene-3-carboxylic acid methyl ester;Methyl 2-amino-5-phenylthiophene-3-carboxylate ,99%;methyl 2-amino-5-phenylthiophene-3-carboxylate(SALTDATA: FREE);3-Thiophenecarboxylic acid, 2-aMino-5-phenyl-, Methyl ester;METHYL 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOXYLAT;2-amino-5-phenyl-3-thiophenecarboxylic acid methyl ester
• CAS NO: 61325-02-8
• Molecular Formula: C₁₂H₁₁NO₂S
• Molecular Weight: 233.28624
• Mol File: 61325-02-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 405.7 °C at 760 mmHg
• Flash Point: 199.1 °C
• Appearance: /
• Density: 1.265 g/cm³
• Vapor Pressure: 8.62E-07mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOXYLATE(61325-02-8)
• EPA Substance Registry System: METHYL 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOXYLATE(61325-02-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61325-02-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-5-phenylthiophene-3-carboxylate is an organic compound distinguished by its chemical structure, which consists of a thiophene ring linked to an amino group and a carboxylate group. Thiophenes are aromatic compounds that contain a five-membered ring of four carbon atoms and one sulfur atom. In this particular compound, the thiophene ring is substituted by a phenyl group at the 5-position, an amino group at the 2-position, and a carboxylate group at the 3-position in the form of a methyl ester. Methyl 2-amino-5-phenylthiophene-3-carboxylate could serve as an intermediate in the synthesis of various organic compounds, but its specific uses, reactivity, and safety information are not widely documented, and proper care should be taken when handling and storing this chemical.

InChI:InChI=1/C12H11NO2S/c1-15-12(14)9-7-10(16-11(9)13)8-5-3-2-4-6-8/h2-7H,13H2,1H3

Upstream product

• 122-78-1 phenylacetaldehyde 
• 105-34-0 methyl 2-cyanoacetate 
• 3709-20-4 dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate 
• 479617-68-0 methyl 1-cyano-2-phenylcyclopropanecarboxylate 
• 1262235-61-9 methyl 2-amino-5-phenyl-4,5-dihydrothiophene-3-carboxylate 
• 570419-61-3 C₁₂H₁₁NO₂ 

Downstream Products

• 859204-50-5 5-phenyl-2-(tetrahydro-2H-thiopyran-4-ylamino)thiophen-3-carboxylic acid methyl ester 
• 38695-72-6 methyl 5-phenylthiophene-3-carboxylate 
• 1187467-82-8 2-bromo-5-phenyl-thiophene-3-carboxylic acid 
• 1402143-79-6 methyl 2-(2-bromo-5-phenylthiophen-3-yl)-2-(tert-butoxy)acetate 
• 1402143-80-9 methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetate 
• 1402143-74-1 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-phenylthiophen-3-yl]acetic acid 
• 1402143-75-2 methyl 2-bromo-5-phenylthiophene-3-carboxylate 
• 1402143-76-3 (2-bromo-5-phenylthiophen-3-yl)methanol 
• 116016-65-0 2-bromo-5-phenylthiophene-3-carbaldehyde 
• 1402143-77-4 2-(2-bromo-5-phenylthiophen-3-yl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 1402143-78-5 methyl 2-(2-bromo-5-phenylthiophen-3-yl)-2-hydroxyacetate 
• 86126-60-5 6-phenylthieno<2,3-d>pyrimidine-2,4-dione 
• 1241495-62-4 N-(tert-butyl)-2-(2,5-dioxo-7-phenyl-1,2,3,5-tetrahydro-4H-thieno[2,3-e][1,4]diazepin-4-yl)acetamide 
• 1240361-35-6 C₂₄H₂₇N₃O₃S 

Relevant articles and documents

Microwave-assisted synthesis of 2-aminothiophene derivatives via improved gewald reactions

In this paper, a new and efficient method was developed to prepare 2-aminothiophene derivatives through improved Gewald reaction. Thirty-one final products were synthesized under microwave radiation for 30 min with 57%-95% isolated yields. All the product

Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease

A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds 8c-i, k, l, bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist 8g, showing the best balance between receptor affinity and selectivity, was tested in vitro in an experimental model of allergic contact dermatitis and proved to be able to block the release of MCP-2 in HaCaT cells at 10 μM concentration.

Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

The phosphatase PTP4A3 is an attractive anticancer target, but knowledge of its exact role in cells remains incomplete. A potent, structurally novel inhibitor of the PTP4A family was obtained by photooxygenation of a less active, electron-rich thienopyrid