C₄₀H₄₁FN₄O₇

Base Information

• Chemical Name: C₄₀H₄₁FN₄O₇
• CAS No.: 1266096-91-6
• Molecular Formula: C₄₀H₄₁FN₄O₇
• Molecular Weight: 708.787
• Mol file: 1266096-91-6.mol

Synonyms:C₄₀H₄₁FN₄O₇

Chemical Property of C₄₀H₄₁FN₄O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₀H₄₁FN₄O₇

There total 17 articles about C₄₀H₄₁FN₄O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

naphth-1-yl acetic acid (86-87-3) + benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride (1264221-69-3) → C40H41FN4O7 (1266096-91-6)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

C15H19NO4*ClH (1264239-42-0) → C40H41FN4O7 (1266096-91-6)

Guidance literature:

Multi-step reaction with 10 steps

1.1: pyridine / dichloromethane / 15 h / 0 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

3.1: thiophenol; caesium carbonate / acetonitrile / 16 h / 20 °C

3.2: 0.08 h

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 0 - 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / benzene / 19 h / 0 - 20 °C / Inert atmosphere

7.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 1.5 h / 20 °C

8.1: pentafluorophenyl diphenyl-phosphinate / N,N-dimethyl-formamide / 20 h / 20 °C

9.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

10.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; pentafluorophenyl diphenyl-phosphinate; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene; 6.1: Mitsunobu reaction;

Reference yield:

C22H24N2O8S (1264239-51-1) → C40H41FN4O7 (1266096-91-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: thiophenol; caesium carbonate / acetonitrile / 16 h / 20 °C

1.2: 0.08 h

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 0 - 20 °C

4.1: triphenylphosphine; diethylazodicarboxylate / benzene / 19 h / 0 - 20 °C / Inert atmosphere

5.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 1.5 h / 20 °C

6.1: pentafluorophenyl diphenyl-phosphinate / N,N-dimethyl-formamide / 20 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

8.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; pentafluorophenyl diphenyl-phosphinate; caesium carbonate; thiophenol; 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene; 4.1: Mitsunobu reaction;

upstream raw materials:

benzyl bromide

naphth-1-yl acetic acid

benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

benzyl (2S,11S,19aS)-2-[(tert-butoxycarbonyl)amino]-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate

Refernces