tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate

Base Information

• Chemical Name: tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate
• CAS No.: 125879-66-5
• Molecular Formula: C₁₅H₁₈ClNO₈S
• Molecular Weight: 407.829
• Mol file: 125879-66-5.mol

Synonyms:tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate

Chemical Property of tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate

There total 2 articles about tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-nitrobenzenesulfonyl peroxide (6209-72-9) + tert-butyl 5-chloro-3-oxopentanoate (88023-66-9) → tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate (125879-66-5)

Guidance literature:

With potassium carbonate; In ethyl acetate; a) 0 deg C, 3h, b) 0 deg C to r.t., overnight;

DOI:10.1021/jo00296a047

Reference yield:

acetic acid tert-butyl ester (540-88-5) → tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate (125879-66-5)

Guidance literature:

Multi-step reaction with 2 steps

2: 71 percent / K₂CO₃ / ethyl acetate / a) 0 deg C, 3h, b) 0 deg C to r.t., overnight

With potassium carbonate; In ethyl acetate;

DOI:10.1021/jo00296a047

Reference yield:

tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate (125879-66-5) → tert-butyl 1-benzyl-3-hydroxypyrrole-2-carboxylate (65171-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: 2) SiO₂

With silica gel; trifluoroacetic acid;

DOI:10.1016/S0040-4020(01)86369-9

upstream raw materials:

4-nitrobenzenesulfonyl peroxide

tert-butyl 5-chloro-3-oxopentanoate

acetic acid tert-butyl ester

Downstream raw materials:

tert-butyl 1-benzyl-3-hydroxypyrrole-2-carboxylate