(R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE

Base Information

Chemical Name:(R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE
CAS No.:1201581-83-0
Molecular Formula:C₁₆H₂₃FN₂O₂
Molecular Weight:294.369
Hs Code.:
Mol file:1201581-83-0.mol

Synonyms:tert-butyl (R)-2-[(3-fluorophenylamino)methyl]pyrrolidine-1-carboxylate

Suppliers and Price of (R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
(R)-1-Boc-2-[(3-Fluoro-phenylamino)-methyl]-pyrrolidine 95
25g
$ 3300.00

American Custom Chemicals Corporation
(R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE 95.00%
5MG
$ 498.95

Total 1 raw suppliers

Chemical Property of (R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE

Chemical Property:

Purity/Quality:: (R)-1-Boc-2-[(3-Fluoro-phenylamino)-methyl]-pyrrolidine 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE

There total 5 articles about (R)-1-BOC-2-[(3-FLUORO-PHENYLAMINO)-METHYL]-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372-19-0
meta-fluoroaniline

: 73365-02-3,117625-90-8
tert-butoxycarbonyl-D-prolinal

: 1201581-83-0
tert-butyl (R)-2-[(3-fluorophenylamino)methyl]pyrrolidine-1-carboxylate

Guidance literature:: meta-fluoroaniline; tert-butoxycarbonyl-D-prolinal; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

With water; In 1,2-dichloro-ethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1201581-83-0
tert-butyl (R)-2-[(3-fluorophenylamino)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tert-butyl alcohol / 21 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 19 h / -20 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7
D-Prolin

: 1201581-83-0
tert-butyl (R)-2-[(3-fluorophenylamino)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tert-butyl alcohol / 21 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 19 h / -20 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; tert-butyl alcohol;