N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

Base Information

Chemical Name:N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide
CAS No.:1389326-56-0
Molecular Formula:C₂₇H₃₅ClN₄O₃SSi
Molecular Weight:559.204
Hs Code.:

Synonyms:N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

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Chemical Property of N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

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Technology Process of N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

There total 9 articles about N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389326-56-0
N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: hydrogenchloride; methanol / 2 h / 20 °C

5.2: pH 9 - 10

6.1: 4-methyl-morpholine / dichloromethane / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

7.2: 2 h / 20 °C

8.1: lithium borohydride; methanol / tetrahydrofuran / 2 h / 20 °C

9.1: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C

10.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

11.1: sodium hydride / dimethyl sulfoxide; mineral oil / 3 h / 20 °C

11.2: 16 h / 70 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; lithium borohydride; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1389326-56-0
N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: hydrogenchloride; methanol / 2 h / 20 °C

5.2: pH 9 - 10

6.1: 4-methyl-morpholine / dichloromethane / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

7.2: 2 h / 20 °C

8.1: lithium borohydride; methanol / tetrahydrofuran / 2 h / 20 °C

9.1: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C

10.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

11.1: sodium hydride / dimethyl sulfoxide; mineral oil / 3 h / 20 °C

11.2: 16 h / 70 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; lithium borohydride; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1389326-47-9
methyl 2-(4-chlorophenyl)-2-(4-nitro-1H-indazol-1-yl)acetate

: 1389326-56-0
N-(1-(1-(4-chlorophenyl)-1-(2-cyanocyclopropyl)propyl)-1H-indazol-4-yl)-N-((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

2.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.1: hydrogenchloride; methanol / 2 h / 20 °C

4.2: pH 9 - 10

5.1: 4-methyl-morpholine / dichloromethane / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

6.2: 2 h / 20 °C

7.1: lithium borohydride; methanol / tetrahydrofuran / 2 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C

9.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C

10.1: sodium hydride / dimethyl sulfoxide; mineral oil / 3 h / 20 °C

10.2: 16 h / 70 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; lithium borohydride; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; hydrogen; sodium hydride; sodium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; 10% Pt/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;