2'-Bromo-4-chlorophenylacetic acid methyl ester

Base Information

• Chemical Name: 2'-Bromo-4-chlorophenylacetic acid methyl ester
• CAS No.: 24091-92-7
• Molecular Formula: C9H8BrClO2
• Molecular Weight: 263.518
• Mol file: 24091-92-7.mol

Synonyms:Aceticacid, bromo(p-chlorophenyl)-, methyl ester (6CI,8CI);2-(4-Chlorophenyl)-2-bromoacetic acid methyl ester;2-Bromo-2-(4-chlorophenyl)acetic acid methyl ester;Bromo(4-chlorophenyl)aceticacid methyl ester;Methyl 2-bromo-2-(4-chlorophenyl)acetate;Methylbromo(4-chlorophenyl)acetate;Methyl a-bromo-4-chlorophenylacetate;Methyl a-bromo-p-chlorobenzeneacetate;Methyl a-bromo-p-chlorophenylacetate;

Chemical Property of 2'-Bromo-4-chlorophenylacetic acid methyl ester

Chemical Property:

• Boiling Point: 149-152 °C(Press: 16 Torr)
• PSA: 26.30000
• Density: 1.567±0.06 g/cm3(Predicted)
• LogP: 2.81800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-bromo-4-chlorophenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-Bromo-4-chlorophenylacetic acid methyl ester

There total 13 articles about 2'-Bromo-4-chlorophenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4-chloro-phenyl)-acetic acid methyl ester (52449-43-1) → methyl 2-bromo-2-(4-chlorophenyl)acetate (24091-92-7)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 5h; Heating;

DOI:10.1016/S0040-4020(02)01397-2

Reference yield: 85.0%

methanol (67-56-1) + 3-(4-chlorophenyl)oxirane-2,2-dicarbonitrile (33512-03-7) → methyl 2-bromo-2-(4-chlorophenyl)acetate (24091-92-7)

Guidance literature:

With hydrogen bromide; for 3h; Heating;

DOI:10.1016/S0040-4020(01)90607-6

Reference yield: 84.0%

methanol (67-56-1) → methyl 2-bromo-2-(4-chlorophenyl)acetate (24091-92-7) + (4-chloro-phenyl)-acetic acid methyl ester (52449-43-1)

Guidance literature:

4-chlorophenylacetic Acid; With thionyl chloride; at 55 ℃; for 1h;

With bromine; at 9 - 80 ℃; for 23.3333h;

methanol;

upstream raw materials:

4-chlorophenacetyl chloride

methanol

3-(4-chlorophenyl)oxirane-2,2-dicarbonitrile

(4-chloro-phenyl)-acetic acid methyl ester

Downstream raw materials:

5-(4-Chloro-phenyl)-2-imino-thiazolidin-4-one

methyl 2-(acetylthio)-2-(4-chlorophenyl)acetate

(R,S)-α-(4-chlorophenyl)-α-[(R)-N-[1-(4-chlorophenyl)ethyl]amino]acetic acid methyl ester

(4-Chloro-phenyl)-{[(R)-1-(4-chloro-phenyl)-ethyl]-[(E)-(3-phenyl-acryloyl)]-amino}-acetic acid methyl ester

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