Technology Process of 2-(6-(4-isobutyl-2-methoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid
There total 5 articles about 2-(6-(4-isobutyl-2-methoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 2-(6-(4-isobutyl-2-methoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate;
With
lithium hydroxide;
In
1,4-dioxane;
at 24 ℃;
for 17h;
With
citric acid;
In
1,4-dioxane;
pH=4 - 5;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluoroacetic acid; water / methanol / 80 °C
2.1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C
3.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 24 °C
3.2: 18 h / 24 °C
3.3: 16 h / 24 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 24 °C
4.2: 2 h / 50 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 19 h / 24 °C
6.1: lithium hydroxide / 1,4-dioxane / 17 h / 24 °C
6.2: pH 4 - 5
With
chloro-trimethyl-silane; tetrabutyl ammonium fluoride; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide;
10% palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C
2.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 24 °C
2.2: 18 h / 24 °C
2.3: 16 h / 24 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 24 °C
3.2: 2 h / 50 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 19 h / 24 °C
5.1: lithium hydroxide / 1,4-dioxane / 17 h / 24 °C
5.2: pH 4 - 5
With
chloro-trimethyl-silane; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
10% palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
![methyl 2-(6-(4-isobutyl-2-methoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate](/Databaselist/images/loading.webp)
