methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

Base Information

• Chemical Name: methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate
• CAS No.: 1262007-84-0
• Molecular Formula: C₂₁H₂₂N₂O₃
• Molecular Weight: 350.417
• Mol file: 1262007-84-0.mol

Synonyms:methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

Chemical Property of methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

There total 2 articles about methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 3,3-dimethoxypropionate (7424-91-1) + 5-benzyloxytryptamine (20776-45-8) → methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate (1262007-84-0)

Guidance literature:

With trifluoroacetic acid; In water; acetonitrile; at 80 ℃;

DOI:10.1016/j.bmcl.2014.11.089

Reference yield:

methyl 3,3-dimethoxypropionate (7424-91-1) + 5-benzyloxytryptamine hydrochloride (52055-23-9) → methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate (1262007-84-0)

Guidance literature:

methyl 3,3-dimethoxypropionate; 5-benzyloxytryptamine hydrochloride; With water; trifluoroacetic acid; In methanol; at 80 ℃;

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate (1262007-84-0) → tert-butyl 6-(benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1262007-96-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

methyl 3,3-dimethoxypropionate

5-benzyloxytryptamine hydrochloride

5-benzyloxytryptamine

Downstream raw materials:

tert-butyl 6-(benzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

methyl 2-(6-(4-isobutyl-2-methoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

2-(6-(4-isobutyl-2-methoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid