1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

Base Information

Chemical Name:1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole
CAS No.:1307854-39-2
Molecular Formula:C₂₇H₄₁N₃O₂Si
Molecular Weight:467.727
Hs Code.:

Synonyms:1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

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Chemical Property of 1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

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Technology Process of 1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

There total 7 articles about 1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1307854-20-1
2-(2-azidoethyl)-1,4-dioxane

: 1307854-13-2
[(2-ethyl-4-ethynylphenyl)ethynyl]triisopropylsilane

: 1307854-39-2
1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In methanol; water; at 20 - 60 ℃;
DOI:10.1002/ejoc.201001531

Reference yield:

: 926624-52-4
2-(2-bromoethyl)-1,4-dioxane

: 1307854-39-2
1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 45 °C

2: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; water / 20 - 60 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In methanol; water; dimethyl sulfoxide;
DOI:10.1002/ejoc.201001531

Reference yield:

: 1307853-93-5
3-ethyl-4-[(triisopropylsilyl)ethynyl]aniline

: 1307854-39-2
1-[2-(1,4-dioxan-2-yl)ethyl]-4-{3-ethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 3 °C

1.2: 2 h / 0 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / toluene / 4 h / Reflux

4.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; water / 20 - 60 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; water; toluene; 1.1: Sandmeyer type reaction / 1.2: Sandmeyer type reaction / 2.1: Sonogashira coupling;
DOI:10.1002/ejoc.201001531