methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

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Chemical Name:methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate
CAS No.:1349197-87-0
Molecular Formula:C₁₈H₂₆N₂O₆S
Molecular Weight:398.48
Hs Code.:

Synonyms:methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

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Technology Process of methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

There total 6 articles about methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1349197-85-8
(1S,4S)-5-(phenylsulfonyl)-2-oxa-5-azabicyclo[2.2.1]heptan-3-one

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1349197-87-0
methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: With sodium hydrogencarbonate; In water; toluene; at 80 ℃; for 6h;
DOI:10.1071/CH11204

Reference yield:

: 16257-76-4
1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1349197-87-0
methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / diethyl ether; water / 96 h / 20 °C

2: potassium carbonate / butanone / 2 h / Reflux

3: sodium hydrogencarbonate / water; toluene / 6 h / 80 °C

With sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In diethyl ether; water; toluene; butanone;
DOI:10.1071/CH11204

Reference yield:

: 16257-78-6
1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1349197-87-0
methyl (S)-2-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / dichloromethane; water / 112 h / 20 °C

2: sodium hydroxide / diethyl ether; water / 96 h / 20 °C

3: potassium carbonate / butanone / 2 h / Reflux

4: sodium hydrogencarbonate / water; toluene / 6 h / 80 °C

With sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In diethyl ether; dichloromethane; water; toluene; butanone;
DOI:10.1071/CH11204