1''-Benzylspiro[chroman-2,4''-piperidine]

Base Information

Chemical Name:1''-Benzylspiro[chroman-2,4''-piperidine]
CAS No.:81109-74-2
Molecular Formula:C₂₀H₂₃NO
Molecular Weight:293.409
Hs Code.:
DSSTox Substance ID:DTXSID901162579
Nikkaji Number:J962.390F
Pharos Ligand ID:ZC7WXFC4ZF4H
ChEMBL ID:CHEMBL38634

Synonyms:CHEMBL38634;SCHEMBL7326095;DTXSID901162579;BDBM50064171;81109-74-2;1''-benzylspiro[chroman-2,4''-piperidine];1'-Benzyl-3,4-dihydrospiro[2H-1-benzopyran-2,4'-piperidine];1''-benzylspiro[3,4-dihydro-2H-chromene-2,4''-(hexahydropyridine)];3,4-Dihydro-1'-(phenylmethyl)spiro[2H-1-benzopyran-2,4'-piperidine]

Suppliers and Price of 1''-Benzylspiro[chroman-2,4''-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 1''-Benzylspiro[chroman-2,4''-piperidine]

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:293.177964357
Heavy Atom Count:22
Complexity:355

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2(CCN(CC2)CC3=CC=CC=C3)OC4=CC=CC=C41

Technology Process of 1''-Benzylspiro[chroman-2,4''-piperidine]

There total 6 articles about 1''-Benzylspiro[chroman-2,4''-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 81109-76-4
1'-benzylspiro<2H-1-benzopyran-2,4'-poperidine>

: 81109-74-2
1'-benzylspiro[chromane-2,4'-piperidine]

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1248/cpb.29.3494

Reference yield: 49.0%

: 77264-89-2
1'-benzylspiro[chromene-2,4'-piperidin]-4(3H)-one

: 81109-74-2
1'-benzylspiro[chromane-2,4'-piperidine]

Guidance literature:: With dimethylsulfide borane complex; In diethylene glycol dimethyl ether; at 120 ℃; for 14h;
DOI:10.1021/jm970740r

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 81109-74-2
1'-benzylspiro[chromane-2,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyrrolidine / methanol / 8 h / Heating

2: 87 percent / NaBH₄, 10 percent NaOH / ethanol / 2 h / Heating

3: 90 percent / 20 percent H₂SO₄ / 1 h / Heating

4: 96 percent / H₂ / 5 percent Pd-C / ethanol

With pyrrolidine; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1248/cpb.29.3494