77264-89-2

Usage

Chemical Structure

1'-Benzyl-3,4-dihydrospiro[1-benzopyran-2,4'-piperidine]-4-one is a complex organic compound with a spiro skeleton, consisting of a piperidine ring fused to a benzene and a benzopyran ring.

Precursor for Synthesis

It is commonly used as a precursor for the synthesis of pharmaceuticals and other organic compounds.

Serotonin Receptor Antagonist

It acts as a serotonin receptor antagonist, making it useful in the treatment of various central nervous system disorders.

Anti-Inflammatory Properties

It has been studied for its anti-inflammatory properties, showing potential for use in inflammation-related conditions.

Analgesic Properties

It has also been studied for its analgesic properties, indicating its potential use in pain management.

Scientific Interest

The compound has garnered interest in the scientific community due to its diverse pharmacological properties.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 693789-31-0 1'-benzylspiro[chromene-2,4'-piperidin]-4(3H)-one oxime 
• 693789-32-1 1'-benzyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1298034-55-5 1'-benzyl-5-ethyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1298034-43-1 5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] hydrochloride 
• 1298034-42-0 1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1298034-61-3 2-(1'-benzyl-3,4-dihydro-5H-spiro[1,5-benzoxazepine-2,4'-piperidin]-5-yl)ethanol 
• 1298034-48-6 1'-benzyl-5-cyclopropyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1298034-45-3 5-cyclopropyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1298034-60-2 1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1024606-02-7 1'-benzyl-5-isopropyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 1298034-44-2 5-ethyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] 
• 81109-76-4 1'-benzylspiro<2H-1-benzopyran-2,4'-poperidine> 
• 81109-74-2 1'-benzylspiro[chromane-2,4'-piperidine] 
• 81109-75-3 1'-benzyl-4-hydroxyspiro- 

Relevant academic research and scientific papers

Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro[1,5- benzoxazepine-2,4′-piperidine] analogs

Expansion of the 6-membered ring and subsequent fine-tuning of the newly obtained 7-membered spiropiperidine structure resulted in the discovery of a series of novel and potent SCD1 inhibitors. Preliminary SAR was explored by modifying an alkyl chain on t

A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening

We report here the design and parallel synthesis of 217 compounds based on a malonic-hydroxamic acid template. These compounds are obtained via a two-step solution-phase procedure. The set of diverse building-blocks used makes this strategy suitable for t

Synthesis of new substituted 4,5-dihydro-3H-spiro[1,5]-benzoxazepine-2, 4′-piperidine and biological properties

The reduction of substituted spiro-piperidinyl chromanone oximes with DIBAH reagents has been known to afford the corresponding substituted 4,5-dihydro-3H-spiro[1,5]-benzoxazepine-2,4?-piperidine. The position and electronic effects of the substituents on

New synthesis of flavanones catalyzed by L-proline

L-Proline is utilized as an efficient organocatalyst for the synthesis of substituted flavanones and chalcones in good yields. The efficiency of the catalyst was proved with a variety of substrates ranging from electron-deficient to electron-rich aryl aldehydes and 2-hydroxyacetophenones.

Synthesis and structural studies of a novel scaffold for drug discovery: A 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4′-piperidine]

We describe the three-step synthesis of a novel 4,5-dihydro-3H-spiro[1,5- benzoxazepine-2,4′-piperidine] scaffold from ortho-hydroxyacetophenone and N-benzylpiperidone. The structure of one disubstituted derivative, studied by NOESY NMR in an aqueous medi