cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Base Information

Chemical Name:cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester
CAS No.:1446086-69-6
Molecular Formula:C₂₈H₂₈N₂O₅
Molecular Weight:472.541
Hs Code.:

Synonyms:cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Suppliers and Price of cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

There total 7 articles about cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1446086-68-5
benzyl 2-(3-carbamoylphenyl)-4-hydroxybenzoate

: 3173-53-3
Cyclohexyl isocyanate

: 1446086-69-6
cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Guidance literature:: With dmap; In 1,4-dioxane; at 45 ℃; for 12h;
DOI:10.1021/jm4007017

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 1446086-69-6
cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: zirconium(IV) chloride / dichloromethane / 1 h / -10 - 20 °C / Inert atmosphere

2: sodium t-butanolate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3: Oxone; sodium hydrogencarbonate / water; acetone / 2 h / 0 °C

4: boron tribromide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

5: potassium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

7: dmap / 1,4-dioxane / 12 h / 45 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Oxone; boron tribromide; zirconium(IV) chloride; sodium hydrogencarbonate; sodium carbonate; potassium hydrogencarbonate; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; 6: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm4007017

Reference yield:

: 28547-28-6
2-bromo-4-hydroxybenzoic acid

: 1446086-69-6
cyclohexylcarbamic acid 6-benzyloxycarbonyl-3′-carbamoylbiphenyl-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

3: dmap / 1,4-dioxane / 12 h / 45 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; potassium hydrogencarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm4007017