2-Bromo-4-hydroxybenzoicacid

Base Information

• Chemical Name: 2-Bromo-4-hydroxybenzoicacid
• CAS No.: 28547-28-6
• Molecular Formula: C7H5BrO3
• Molecular Weight: 217.019
• Hs Code.: 2918999090
• Mol file: 28547-28-6.mol

Synonyms:2-Bromo-4-hydroxy-benzoic acid;Benzoic acid, 2-bromo-4-hydroxy-;2-Brom-4-hydroxy-benzoesaeure;2-Br-4-OHC6H3CO2H;

Chemical Property of 2-Bromo-4-hydroxybenzoicacid

Chemical Property:

• Melting Point: 151 °C
• Boiling Point: 366.3±32.0 °C(Predicted)
• PKA: 3.22±0.10(Predicted)
• PSA: 57.53000
• Density: 1.861±0.06 g/cm3(Predicted)
• LogP: 1.85290
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% purity ^*data from raw suppliers

2-Bromo-4-hydroxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-hydroxybenzoicacid

There total 8 articles about 2-Bromo-4-hydroxybenzoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-bromo-4-aminobenzoic acid (2486-52-4) → 2-bromo-4-hydroxybenzoic acid (28547-28-6)

Guidance literature:

2-bromo-4-aminobenzoic acid; With sulfuric acid; sodium nitrite; In water; at 2 ℃; for 1h;

With sulfuric acid; water; at 65 ℃; for 48h; Large scale reaction;

DOI:10.1002/anie.200705313

Reference yield: 88.0%

2-bromo-4-hydroxybenzaldehyde (22532-60-1) → 2-bromo-4-hydroxybenzoic acid (28547-28-6)

Guidance literature:

With potassium permanganate; sodium hydroxide; In water; at 20 ℃; for 2h; Cooling with ice;

Reference yield: 61.0%

2-bromo-4-methoxybenzoic acid (74317-85-4) → 2-bromo-4-hydroxybenzoic acid (28547-28-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm4007017

upstream raw materials:

2-bromo-4-methoxybenzoic acid

2-bromo-4-aminobenzoic acid

3-methoxyphenyl bromide

1-(2-bromo-4-methoxyphenyl)ethanone

Downstream raw materials:

benzyl 3-nitro-4-methoxycarbonylbenzoate

2-{tert-butoxyoxalyl-[4-(3-oxo-butyl)-naphthalen-1-yl]-amino}-benzoic acid benzhydryl ester

2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid benzhydryl ester

2-(tert-butoxyoxalyl-{4-[2-methoxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-naphthalen-1-yl}-amino)-benzoic acid benzhydryl ester

Refernces

• 1、 Moreno-Sanz, Guillermo,Duranti, Andrea,Melzig, Laurin,Fiorelli, Claudio,Ruda, Gian Filippo,Colombano, Giampiero,Mestichelli, Paola,Sanchini, Silvano,Tontini, Andrea,Mor, Marco,Bandiera, Tiziano,Scarpelli, Rita,Tarzia, Giorgio,Piomelli, Daniele. "Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors". . p. 5917 - 5930. Retrieved 2013/08/23.