Technology Process of (1R,3R,4S)-4-bromo-3-hydroxy-cyclohexanecarboxylic acid amide
There total 1 articles about (1R,3R,4S)-4-bromo-3-hydroxy-cyclohexanecarboxylic acid amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide
2: ammonia / water / 24 h / 20 °C
With
trimethylsilyl bromide; ammonia; N-ethyl-N,N-diisopropylamine;
In
water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.09.114
- Guidance literature:
-
With
sodium azide;
In
DMF (N,N-dimethyl-formamide);
at 60 ℃;
for 15.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium azide / N,N-dimethyl-formamide / 15.5 h / 60 °C
2: palladium on activated charcoal; hydrogen / methanol / 22 h / 20 °C / 760.05 Torr
3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; methanol / 16 h
With
sodium azide; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.114
