tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

Base Information

Chemical Name:tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate
CAS No.:1312770-18-5
Molecular Formula:C₃₁H₄₁ClN₆O₇
Molecular Weight:645.156
Hs Code.:

Synonyms:tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

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Chemical Property of tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

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Technology Process of tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

There total 4 articles about tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312770-11-8
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

: 57-14-7
N,N-Dimethylhydrazine

: 1312770-18-5
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

Guidance literature:: With mercury(II) diacetate; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 1312770-12-9
tert-butyl 4-[(1R)-1-isocyanatobutyl]-2-nitrobenzoate

: 1312770-18-5
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / acetonitrile; tetrahydrofuran / 1 h / Cooling with ice

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 15 h / 20 °C

3: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 4 h / Cooling with ice

4: mercury(II) diacetate / isopropyl alcohol; tetrahydrofuran / 3 h / 20 °C / Cooling with ice

With potassium tert-butylate; mercury(II) diacetate; water; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1312770-14-1
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

: 1312770-18-5
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazon)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 4 h / Cooling with ice

2: mercury(II) diacetate / isopropyl alcohol; tetrahydrofuran / 3 h / 20 °C / Cooling with ice

With mercury(II) diacetate; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; In tetrahydrofuran; isopropyl alcohol;