ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

Base Information

Chemical Name:ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate
CAS No.:1168134-72-2
Molecular Formula:C₂₂H₂₂ClF₃O₃
Molecular Weight:426.863
Hs Code.:

Synonyms:ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

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Chemical Property of ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

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Technology Process of ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

There total 6 articles about ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1168134-71-1
ethyl 1-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)cyclobutanecarboxylate

: 5720-05-8
4-methylphenylboronic acid

: 1168134-72-2
ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

Guidance literature:: With cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 100 ℃;

Reference yield:

: 17138-28-2
(4-hydroxy-phenyl)-acetic acid ethyl ester

: 1168134-72-2
ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux

2: bromine / chloroform / 1 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

4: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuryl dichloride; bromine; sodium hydride; potassium carbonate; cesium fluoride; In methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide; paraffin oil;

Reference yield:

: 193357-36-7
3-chloro-4-hydroxyphenylacetic acid ethyl ester

: 1168134-72-2
ethyl 1-(5-chloro-4'-methyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / chloroform / 1 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

3: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; potassium carbonate; cesium fluoride; In 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; paraffin oil;