1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester
• CAS No.: 1448314-36-0
• Molecular Formula: C₁₇H₁₃N₃O₅
• Molecular Weight: 339.307
• Mol file: 1448314-36-0.mol

Synonyms:1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester

Chemical Property of 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester

There total 3 articles about 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

methyl 5-nitro-1H-indazole-3-carboxylate (78155-75-6) + 3-Methylbenzoyl chloride (1711-06-4) → 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester (1448314-36-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1021/jm400742j

Reference yield:

methyl 1H-indazole-3-carboxylate (43120-28-1) → 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester (1448314-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 0.17 h / 0 °C

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With sulfuric acid; nitric acid; triethylamine; In dichloromethane;

DOI:10.1021/jm400742j

Reference yield:

1H-Indazole-3-carboxylic acid (4498-67-3) → 1-(3-methylbenzoyl)-5-nitro-1H-indazole-3-carboxylic acid methyl ester (1448314-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 5 h / Reflux

2: nitric acid; sulfuric acid / 0.17 h / 0 °C

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With sulfuric acid; nitric acid; triethylamine; In dichloromethane;

DOI:10.1021/jm400742j

upstream raw materials:

methyl 1H-indazole-3-carboxylate

methyl 5-nitro-1H-indazole-3-carboxylate

3-Methylbenzoyl chloride

1H-Indazole-3-carboxylic acid