alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

Base Information

Chemical Name:alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester
CAS No.:807640-36-4
Molecular Formula:C₂₅H₃₀ClN₅O₅
Molecular Weight:515.997
Hs Code.:

Synonyms:alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

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Chemical Property of alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

There total 8 articles about alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 807640-36-4
alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 2 h / 80 °C

2.1: methanol; ammonia / 18 h / 20 °C

3.1: caesium carbonate / ISOPROPYLAMIDE / 0.75 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With methanol; ammonia; caesium carbonate; trifluoroacetic acid; In dichloromethane; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

: alanine, N-[[4-chloro-2-[[6-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-7-methoxy-4-quinazolinyl]amino]phenyl]acetyl]-2-methyl-, ethyl ester

: 807640-36-4
alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1056010-58-2
alanine, N-[(4-chloro-2-nitrophenyl)acetyl]-2-methyl-, ethyl ester

: 807640-36-4
alanine, N-[[2-[[6-(2-aminoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-2-methyl-, ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: thiophene; hydrogen / 5 % platinum on carbon / tetrahydrofuran; ethanol / 50 °C

2.1: acetonitrile / 2 h / 80 °C

3.1: methanol; ammonia / 18 h / 20 °C

4.1: caesium carbonate / ISOPROPYLAMIDE / 0.75 h / 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With thiophene; methanol; ammonia; hydrogen; caesium carbonate; trifluoroacetic acid; 5 % platinum on carbon; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; acetonitrile;