3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

Base Information

• Chemical Name: 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
• CAS No.: 179688-53-0
• Molecular Formula: C11H10N2O4
• Molecular Weight: 234.211
• Hs Code.: 2933990090
• Mol file: 179688-53-0.mol

Synonyms:6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one;6-Acetoxy-7-methoxyquinazolin-4(3H)-one;6-Acetoxy-7-methoxyquinazolin-4-one;Acetic acid 4-hydroxy-7-methoxyquinazolin-6-yl ester;3,4-Dihydro-4-oxo-6-acetyloxy-7-methoxyquinazoline;4(1H)-Quinazolinone,6-(acetyloxy)-7-methoxy- (9CI);3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline;

Chemical Property of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 293 °C
• Refractive Index: 1.612
• Boiling Point: 390.518 °C at 760 mmHg
• PKA: 0.67±0.20(Predicted)
• Flash Point: 189.979 °C
• PSA: 81.28000
• Density: 1.395 g/cm³
• LogP: 0.85700
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-7-methoxyquinazolin-6-ylEsterAceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid exhibit potent inhibitory activity against VEGFR-2/HDAC and a human breast cancer cell line MCF-7.

Technology Process of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

There total 37 articles about 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

acetic anhydride (108-24-7) + 6-hydroxy-7-methoxyquinazolin-4(3H)-one (179688-52-9) → 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (179688-53-0)

Guidance literature:

With pyridine; at 100 ℃; for 4h;

Reference yield: 96.0%

→ 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (179688-53-0)

Guidance literature:

Reference yield: 87.0%

acetic anhydride (108-24-7) + 3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (179688-53-0)

Guidance literature:

3H-6,7-dimethoxyquinazolin-4-one; With methanesulfonic acid; DL-methionine; at 120 ℃; for 24h;

acetic anhydride; With pyridine; at 100 ℃; for 22h;

DOI:10.1016/j.ejmech.2018.01.094

upstream raw materials:

acetic anhydride

3H-6,7-dimethoxyquinazolin-4-one

6-hydroxy-7-methoxyquinazolin-4(3H)-one

methyl 2-amino-4,5-dimethoxybenzoate

Downstream raw materials:

6-acetoxy-4-chloro-7-methoxyquinazoline

4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt

6,7-dihydroxyquinazolin-4(3H)-one

N-(3-bromophenyl)-6-(2-[18F]fluoroethoxy)-7-methoxyquinazolin-4-amine

Refernces

• 1、 -. "QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF". Paragraph 00209. . Retrieved 2020/10/09.
• 2、 Li, Zhe,Huang, Yiyou,Wu, Yinuo,Chen, Jingyi,Wu, Deyan,Zhan, Chang-Guo,Luo, Hai-Bin. "Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10". . p. 2099 - 2111. Retrieved 2019/02/26.