2-(4-bromophenyl)-2-phenyloxirane

Base Information

• Chemical Name: 2-(4-bromophenyl)-2-phenyloxirane
• CAS No.: 1070671-69-0
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.145
• Mol file: 1070671-69-0.mol

Synonyms:2-(4-bromophenyl)-2-phenyloxirane

Chemical Property of 2-(4-bromophenyl)-2-phenyloxirane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-bromophenyl)-2-phenyloxirane

There total 5 articles about 2-(4-bromophenyl)-2-phenyloxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-bromophenyl)(phenyl)methanone (90-90-4) + trimethylsulphonium iodide (2181-42-2) → 2-(4-bromophenyl)-2-phenyloxirane (1070671-69-0)

Guidance literature:

trimethylsulphonium iodide; With sodium hydride; In tetrahydrofuran; at 55 ℃; for 6h;

(4-bromophenyl)(phenyl)methanone; In tetrahydrofuran; at 55 ℃; for 16h;

Reference yield: 99.0%

(4-bromophenyl)(phenyl)methanone (90-90-4) + trimethylsulfoxonium iodide (1774-47-6) → 2-(4-bromophenyl)-2-phenyloxirane (1070671-69-0)

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In tetrahydrofuran; at 55 ℃; Inert atmosphere;

(4-bromophenyl)(phenyl)methanone; In tetrahydrofuran; at 55 ℃; for 16h; Inert atmosphere;

Reference yield: 99.0%

(4-bromophenyl)(phenyl)methanone (90-90-4) → 2-(4-bromophenyl)-2-phenyloxirane (1070671-69-0)

Guidance literature:

With trimethylsulfoxonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 55 ℃; for 16h; Inert atmosphere;

upstream raw materials:

(4-bromophenyl)(phenyl)methanone

trimethylsulfoxonium iodide

4-bromophenyllithium

1-chloroacetophenone

Downstream raw materials:

1-(4-Bromo-phenyl)-2-imidazol-1-yl-1-phenyl-ethanol

2-(4-bromophenyl)-2-phenylethanal

C₁₄H₁₃BrO

diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINES". Page/Page column 61;62. . Retrieved 2013/04/10.
• 2、 Wright, Stephen W.,Harris, Richard R.,Collins, Robert J.,Corbett, Ronald L.,Green, Alicia M.,et al.. "Novel 1-(Pyridylphenyl)-1-phenyl-2-imidazolylethanols with Topical Antiinflammatory Activity". . p. 3148 - 3155. Retrieved 2007/10/02.