2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

Base Information

Chemical Name:2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide
CAS No.:1421922-23-7
Molecular Formula:C₂₁H₂₁N₃O₃S
Molecular Weight:395.482
Hs Code.:

Synonyms:2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

Suppliers and Price of 2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

There total 7 articles about 2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421922-22-6
2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole-5-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1421922-23-7
2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 16213-85-7
(2,5-dimethylphenyl)acetonitrile

: 1421922-23-7
2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid / 0.5 h / Cooling with ice

2: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

3: isopropyl alcohol / 2 h / 80 °C

4: sodium hydroxide; water / methanol / 4 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; water; nitric acid; benzotriazol-1-ol; O,O-Diethyl hydrogen phosphorodithioate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1421922-03-3
(2,5-dimethyl-4-nitrophenyl)acetonitrile

: 1421922-23-7
2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

2: isopropyl alcohol / 2 h / 80 °C

3: sodium hydroxide; water / methanol / 4 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; O,O-Diethyl hydrogen phosphorodithioate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;