tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

Base Information

Chemical Name:tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate
CAS No.:1360804-80-3
Molecular Formula:C₂₈H₄₆N₂O₄
Molecular Weight:474.684
Hs Code.:

Synonyms:tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

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Chemical Property of tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

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Technology Process of tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

There total 12 articles about tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1360804-79-0
3-[2-(2-methylphenyl)]-1,3-dioxolan-2-propyl methylsulfonate

: 1205749-79-6
C₁₅H₃₀N₂O₂

: 1360804-80-3
tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

Guidance literature:: With triethylamine; In acetonitrile; at 110 ℃; Sealed tube;
DOI:10.1021/jm201348t

Reference yield:

: 41661-47-6
piperidin-4-one

: 1360804-80-3
tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; toluene / 0 °C / Cooling

1.2: 2 h / 20 °C

2.1: lithium diisopropyl amide / 0.33 h / -78 °C

2.2: 3 h / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 6 h / 20 °C

4.1: platinum(IV) oxide; hydrogen; acetic acid / ethanol / 3361.55 Torr

5.1: triethylamine / acetonitrile / 110 °C / Sealed tube

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; acetic acid; triethylamine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; toluene; acetonitrile;
DOI:10.1021/jm201348t

Reference yield:

: 932-31-0
ortho-tolylmagnesium bromide

: 1360804-80-3
tert-butyl 5-[1-(3-(2-o-tolyl-1,3-dioxolan-2-yl)propyl)piperidin-4-yl]pentylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: sulfuric acid / Reflux

3: toluene-4-sulfonic acid / benzene / 48 h / Reflux

4: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C

5: dichloromethane

6: triethylamine / acetonitrile / 110 °C / Sealed tube

With lithium aluminium tetrahydride; sulfuric acid; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1021/jm201348t