3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

Base Information

Chemical Name:3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid
CAS No.:1354826-19-9
Molecular Formula:C₃₂H₃₀F₃N₃O₄S
Molecular Weight:609.669
Hs Code.:

Synonyms:3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

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Chemical Property of 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

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Technology Process of 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

There total 14 articles about 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1354826-28-0
methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

: 1354826-19-9
3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

Guidance literature:: methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 15 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield:

: 113259-79-3
5-(piperidin-1-yl)-2-nitrobenzaldehyde

: 1354826-19-9
3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

1.2: 4.5 h / -80 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

2.2: 1 h / -80 - -20 °C

3.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

4.1: pyridine / tetrahydrofuran / 3 h / 10 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol / 6 h / Reflux

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 °C

6.2: pH 5

With pyridine; n-butyllithium; oxalyl dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 1354826-19-9
3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)-carbamoyl)-benzylthio)-propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / toluene / Reflux

2.1: Reflux

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

4.2: 4.5 h / -80 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

5.2: 1 h / -80 - -20 °C

6.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

7.1: pyridine / tetrahydrofuran / 3 h / 10 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol / 6 h / Reflux

9.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 °C

9.2: pH 5

With pyridine; hydrogenchloride; n-butyllithium; oxalyl dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;