methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Base Information

Chemical Name:methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate
CAS No.:1354826-28-0
Molecular Formula:C₃₃H₃₂F₃N₃O₄S
Molecular Weight:623.696
Hs Code.:

Synonyms:methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Suppliers and Price of methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

There total 13 articles about methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1354826-26-8
methyl 3-(3-((2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

: 1354826-28-0
methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; for 6h; Reflux;

Reference yield:

: 26908-35-0
5-chloro-2-nitrobenzaldehyde ethylene acetal

: 1354826-28-0
methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

3.2: 4.5 h / -80 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

4.2: 1 h / -80 - -20 °C

5.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

6.1: pyridine / tetrahydrofuran / 3 h / 10 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol / 6 h / Reflux

With pyridine; hydrogenchloride; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; water; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 13544-43-9
6-(trifluoromethyl)-1H-indole

: 1354826-28-0
methyl 3-(3-((4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)carbamoyl)benzylthio)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

2.2: 4.5 h / -80 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

3.2: 1 h / -80 - -20 °C

4.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

5.1: pyridine / tetrahydrofuran / 3 h / 10 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol / 6 h / Reflux

With pyridine; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;