(4-Biphenylyl)glyoxyloyl chloride, oxime

Base Information

• Chemical Name: (4-Biphenylyl)glyoxyloyl chloride, oxime
• CAS No.: 5337-28-0
• Molecular Formula: C14H10ClNO2
• Molecular Weight: 259.692
• NSC Number: 769
• DSSTox Substance ID: DTXSID00429979
• Mol file: 5337-28-0.mol

Synonyms:NSC769;5337-28-0;DTXSID00429979;NSC-769;(4-BIPHENYLYL)GLYOXYLOYL CHLORIDE, OXIME

Chemical Property of (4-Biphenylyl)glyoxyloyl chloride, oxime

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 453.951°C at 760 mmHg
• Flash Point: 228.342°C
• Density: 1.239g/cm³
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 259.0400063
• Heavy Atom Count: 18
• Complexity: 316

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)C(=NO)Cl
• Isomeric SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)/C(=N/O)/Cl

Technology Process of (4-Biphenylyl)glyoxyloyl chloride, oxime

There total 2 articles about (4-Biphenylyl)glyoxyloyl chloride, oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(chloroacetyl)biphenyl (635-84-7) → 2-biphenyl-4-yl-glyoxylohydroximoyl chloride (5337-28-0)

Guidance literature:

With hydrogenchloride; diethyl ether; i-propyl nitrite;

DOI:10.1021/jo01199a002

Reference yield:

4-(chloroacetyl)biphenyl (635-84-7) → 1-(biphenyl-4-yl)-2-chloro-2-(hydroxyimino)ethan-1-one (5337-28-0)

Guidance literature:

With hydrogenchloride; alkyl nitrite;

Reference yield: 81.0%

1-(biphenyl-4-yl)-2-chloro-2-(hydroxyimino)ethan-1-one (5337-28-0) + 4-amino-o-xylene (95-64-7) → 2-([1,1′-biphenyl]-4-yl)-N-(3,4-dimethylphenyl)-N′-hydroxy-2-oxoacetimidamide

Guidance literature:

In ethanol; at -5 - 20 ℃; for 4.25h;

DOI:10.1016/j.molliq.2019.03.169

upstream raw materials:

4-(chloroacetyl)biphenyl

Downstream raw materials:

(p-phenylphenyl)ethanolamine

2-(biphenyl-4-yl)-N'-hydroxy-N-(4-methylphenyl)-2-oxoacetimidamide

2-(biphenyl-4-yl)-N-(4-chlorophenyl)-N'-hydroxy-2-oxoacetimidamide

4-(2-hydroxo-5-chlorophenylaminoisonitrosoacetyl)biphenyl