(R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester

Base Information

• Chemical Name: (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester
• CAS No.: 191275-11-3
• Molecular Formula: C₃₄H₄₁N₃O₅
• Molecular Weight: 571.717
• Mol file: 191275-11-3.mol

Synonyms:(R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester

Chemical Property of (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester

There total 2 articles about (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl phenylcyanoacetate (4553-07-5) → (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester (191275-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / H₂, aq. HCl / 10percent Pd/C / ethanol / 18 h / 30 °C / 2327.2 Torr

2: 1.) 1-hydroxybenzotriazole hydrate (HOBt), N,N'-dicyclohexylcarbodimide, 2.) Et₃N / 1.) EtOAc, RT, 1 h, 2.) EtOAc, RT, 16 h

With hydrogenchloride; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;

DOI:10.1016/0223-5234(93)90078-S

Reference yield:

ethyl (RS)-α-(aminomethyl)benzene acetate hydrochloride (29753-99-9) + N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane (130406-40-5) → (R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester (191275-11-3)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) EtOAc, RT, 1 h, 2.) EtOAc, RT, 16 h;

DOI:10.1016/0223-5234(93)90078-S

Reference yield: 55.0%

(R)-benzeneacetic acid α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>ethyl ester (191275-11-3) → (R)-α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>benzeneacetic acid (191169-84-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 25h;

DOI:10.1016/0223-5234(93)90078-S

upstream raw materials:

ethyl (RS)-α-(aminomethyl)benzene acetate hydrochloride

N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane

ethyl phenylcyanoacetate

Downstream raw materials:

(R)-α-<<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl>benzeneacetic acid