3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

Base Information

Chemical Name:3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile
CAS No.:1591829-42-3
Molecular Formula:C₂₀H₁₅F₆N₅O₃
Molecular Weight:487.361
Hs Code.:

3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

Synonyms:3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

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Chemical Property of 3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

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Technology Process of 3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

There total 11 articles about 3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591829-10-5
2-fluoro-3-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591829-40-1
4-(chloromethyl)-6-(1,1-difluoroethyl)-3-methoxypyridazine

: 1591829-42-3
3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 1722-10-7
3-chloro-6-methoxypyridazine

: 1591829-42-3
3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: toluene

2: hydrogenchloride / 1,4-dioxane

3: diethylamino-sulfur trifluoride / dichloromethane

4: silver nitrate / water; trifluoroacetic acid; ethyl acetate

5: triethylamine / dichloromethane

6: potassium carbonate / N,N-dimethyl-formamide

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium carbonate; silver nitrate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;

Reference yield:

: 1591827-18-7
4-(tert-butoxymethyl)-6-chloro-3-methoxypyridazine

: 1591829-42-3
3-((1-((6-(1,1-difluoroethyl)-3-methoxy-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: toluene

2: hydrogenchloride / 1,4-dioxane

3: diethylamino-sulfur trifluoride / dichloromethane

4: hydrogenchloride / dichloromethane; methanol

5: triethylamine / dichloromethane

6: potassium carbonate / N,N-dimethyl-formamide

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;