3-Chloro-6-methoxypyridazine

Base Information

• Chemical Name: 3-Chloro-6-methoxypyridazine
• CAS No.: 1722-10-7
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.56
• Hs Code.: 2933990090
• European Community (EC) Number: 217-019-7
• NSC Number: 522667,69819
• UNII: 4NE4MDH8HE
• DSSTox Substance ID: DTXSID10169213
• Nikkaji Number: J101.371H
• Wikidata: Q72453400
• Mol file: 1722-10-7.mol

Synonyms:3-CHLORO-6-METHOXYPYRIDAZINE;1722-10-7;Pyridazine, 3-chloro-6-methoxy-;3-chloro-6-methoxy-pyridazine;4NE4MDH8HE;EINECS 217-019-7;MFCD00006467;NSC-69819;NSC-522667;3-Chloro-6-Methoxypyridazine,97%;Pyridazine,3-chloro-6-methoxy-;NSC69819;O(C)c1ccc(Cl)nn1;UNII-4NE4MDH8HE;3-methoxy-6-chloropyridazine;SCHEMBL321951;3-chloro-6-methoxy pyridazine;DTXSID10169213;STR05479;6-chloropyridazin-3-yl methyl ether;3-Chloro-6-methoxypyridazine, 95%;NSC 69819;NSC522667;STK506190;AKOS000164160;CCG-321474;CS-W001168;NSC 522667;PB28962;AC-25151;AM100362;BP-10484;SY025139;C2376;FT-0615442;EN300-65379;P10018;A811386;A854111;AC-907/25014054;W-206021;2-chloro-5-methoxy-pyrazine;3-Chloro-6-methoxypyridazine;4-(3-BUTYL-2,3-DIHYDRO-1H-IMIDAZOL-1-YL)BUTANE-1-SULPHONICACID

Chemical Property of 3-Chloro-6-methoxypyridazine

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0.00498mmHg at 25°C
• Melting Point: 84-85 °C(lit.)
• Refractive Index: 1.52
• Boiling Point: 284.892 °C at 760 mmHg
• PKA: 0.74±0.10(Predicted)
• Flash Point: 126.099 °C
• PSA: 35.01000
• Density: 1.293 g/cm³
• LogP: 1.13860
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 144.0090405
• Heavy Atom Count: 9
• Complexity: 91

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-6-methoxypyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=NN=C(C=C1)Cl
• Uses: 3-Chloro-6-methoxypyridazine was used in the preparation of number of α-aryl-α-(pyridazin-3-yl)-acetonitriles.

Technology Process of 3-Chloro-6-methoxypyridazine

There total 9 articles about 3-Chloro-6-methoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,6-dichlorpyridazine (141-30-0) + sodium methylate (124-41-4) → 3-chloro-6-methoxypyridazine (1722-10-7)

Guidance literature:

DOI:10.1002/jhet.5570420406

Reference yield: 90.0%

calcium carbide (75-20-7) + 3-chloro-6-methoxy-1,2,4,5-tetrazine → 3-chloro-6-methoxypyridazine (1722-10-7)

Guidance literature:

With water; In 1,4-dioxane; at 100 ℃; for 120h; Sealed tube;

DOI:10.1002/asia.202100562

Reference yield: 90.0%

benzyl vinyl ether (935-04-6) + 3-chloro-6-methoxy-1,2,4,5-tetrazine → 3-chloro-6-methoxypyridazine (1722-10-7)

Guidance literature:

In 1,4-dioxane; at 100 ℃; Sealed tube;

DOI:10.1002/asia.202100562

upstream raw materials:

3,6-dichlorpyridazine

sodium methylate

3-methoxypyridazine 1-oxide

chloroform

Downstream raw materials:

3-methoxy-6-phenoxy-pyridazine

6-methoxy-3-(phenylsulfanyl)pyridazine

6-Chlor-3-methoxy-pyridazin-1-oxid

3-methoxypyridazine