(E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one

Base Information

• Chemical Name: (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one
• CAS No.: 1207454-65-6
• Molecular Formula: C₁₈H₁₇FN₂O₂
• Molecular Weight: 312.344
• Mol file: 1207454-65-6.mol

Synonyms:(E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one

Chemical Property of (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one

There total 7 articles about (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-amino-6-fluoroisobenzofuran-1(3H)-one (1207453-91-5) + 4-(dimethylaminomethyl)benzaldehyde (36874-95-0) → (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one (1207454-65-6)

Guidance literature:

With magnesium sulfate; In acetonitrile; for 48h; Product distribution / selectivity; Reflux;

Reference yield: 60.0%

4-Amino-1(3H)-isobenzofuranon (59434-19-4) + 4-(dimethylaminomethyl)benzaldehyde (36874-95-0) → (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one (1207454-65-6)

Guidance literature:

With magnesium sulfate; In acetonitrile; for 48h; Product distribution / selectivity; Reflux;

Reference yield:

3-nitrophthalic acid anhydride (641-70-3) → (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one (1207454-65-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: magnesium sulfate / acetonitrile / 48 h / Reflux

With sodium tetrahydroborate; hydrogen; magnesium sulfate; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; acetonitrile;

upstream raw materials:

4-amino-6-fluoroisobenzofuran-1(3H)-one

4-(dimethylaminomethyl)benzaldehyde

3-nitrophthalic acid anhydride

terephthalaldehyde,

Downstream raw materials:

ethyl 2-(4-((dimethylamino)methyl)phenyl)-7-fluoro-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

ethyl 2-(4-((dimethylamino)methyl)phenyl)-7-fluoro-3-(4-fluorophenyl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

ethyl 2,3-bis(4-((dimethylamino)methyl)phenyl)-7-fluoro-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

ethyl 2-(4-((dimethylamino)methyl)phenyl)-7-fluoro-4-oxo-3-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate