36874-95-0

Basic information

• Product Name: 4-DIMETHYLAMINOMETHYL-BENZALDEHYDE
• Synonyms: 4-DIMETHYLAMINOMETHYL-BENZALDEHYDE;Benzaldehyde, 4-((dimethylamino)methyl)-;p-Dimethylaminomethylbenzaldehyde;4-[(Dimethylamino)methyl]benzaldehyde HCl
• CAS NO: 36874-95-0
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 36874-95-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 241.2°Cat760mmHg
• Flash Point: 81.4°C
• Appearance: /
• Density: 1.035g/cm³
• Vapor Pressure: 0.0363mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 4-DIMETHYLAMINOMETHYL-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHYLAMINOMETHYL-BENZALDEHYDE(36874-95-0)
• EPA Substance Registry System: 4-DIMETHYLAMINOMETHYL-BENZALDEHYDE(36874-95-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 36874-95-0(Hazardous Substances Data)

Usage

General Description

4-dimethylaminomethyl-benzaldehyde, also known as p- (dimethylamino) benzaldehyde, is a chemical compound commonly used in organic synthesis and as a reagent in chemical reactions. It is a colorless to pale yellow liquid with a strong fruity odor, and is primarily used as a building block in the synthesis of various pharmaceuticals, dyes, and other organic compounds. Its chemical structure contains a benzene ring with a formyl group and a dimethylamino group attached at the para position, which gives it its unique characteristics and reactivity in chemical reactions. It is important to handle and store 4-dimethylaminomethyl-benzaldehyde with proper safety precautions, as it can be harmful if ingested, inhaled, or comes into contact with skin or eyes. Overall, 4-dimethylaminomethyl-benzaldehyde is a versatile and important chemical compound with various industrial and laboratory applications.

InChI:InChI=1/C10H13NO/c1-11(2)7-9-3-5-10(8-12)6-4-9/h3-6,8H,7H2,1-2H3

Upstream product

• 34490-85-2 1-N,N-dimethylaminomethyl-4-aminomethylbenzene 
• 126631-48-9 α-(2-bromo-6,11-dihydrodibenzothiepin-11-yl)-4-(dimethylaminomethyl)benzyl alcohol 
• 13990-98-2 4-<(dimethylamino)methyl>benzyl alcohol 
• 18153-53-2 methyl 4-(N,N-dimethylaminomethyl)benzoate 
• 6274-57-3 (4-bromobenzyl)dimethylamine 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 217662-06-1 1-(4-(diethoxymethyl)phenyl)-N,N-dimethylmethanamine 
• 623-27-8 terephthalaldehyde, 
• 81172-89-6 terephthalaldehyde mono(diethylacetal) 
• 201230-82-2 carbon monoxide 
• 140621-52-9 1-(4-iodophenyl)-N,N-dimethylmethanamine 
• 624-31-7 4-tolyl iodide 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 51359-78-5 4-(bromomethyl)benzaldehyde 

Downstream Products

• 1043508-59-3 1-(tert-butyloxycarbonyl)-4-[(4-((dimethylamino)methyl)phenyl)methyl]piperazine 
• 1207454-65-6 (E)-4-(4-((dimethylamino)methyl)benzylideneamino)-6-fluoroisobenzofuran-1(3H)-one 
• 439690-28-5 4-[(dimethylamino)methyl]benzaldehyde (6-tert-butylthieno[2,3-d]pyrimidin-4-yl)hydrazone 
• 1207455-33-1 ethyl 2,3-bis(4-((dimethylamino)methyl)phenyl)-7-fluoro-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1246935-94-3 6-(4-dimethylaminomethyl-phenyl)-fulvene 
• 1391916-73-6 C₃₉H₄₀BF₂IN₄ 
• 1397866-98-6 C₂₂H₂₆BF₂N₃ 
• 1428969-16-7 2-(4-((dimethylamino)methyl)phenyl)-1-(1H-indol-3-yl)-2-((3-methoxyphenyl)amino)ethanone 
• 1428972-70-6 N-(4-((dimethylamino)methyl)benzylidene)-3-methoxyaniline 
• 1366232-69-0 C₂₄H₂₆N₄O 
• 72035-45-1 (R,S)-3-[4-(dimethylamino)phenyl]-2-phenylpropanenitrile 
• 1222-61-3 (Z)-3-(4-(dimethylamino)phenyl)-2-phenylacrylonitrile 
• 1361503-71-0 (Z)-3-{4-[(dimethylamino)methyl]phenyl}-2-phenylacrylonitrile hydrochloride 
• 1207453-17-5 8,9-bis(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 

Relevant articles and documents

DIAMINE OXIDASE FROM LENS ESCULENTA SEEDLINGS: PURIFICATION AND PROPERTIES

A diamine oxidase (DAO) (EC 1.4.3.6) has been purified to homogeneity from lentil seedlings.The purified protein has a MW of 154000 and is composed of two apparently identical subunits.It contains two Cu(2+) atoms and one carbonyl-like group per mol.The purified enzyme is pink-red in concentrated solution and shows a broad, well-defined, absorption band in the visible region centered at 498 nm.The ESR spectrum is typical of Cu(2+) in a tetragonal symmetry.The enzyme oxidizes only aliphatic diamines and spermidine with formation of the corresponding aldehydes, hydrogen peroxide and ammonia.Putrescine and cadaverine are oxidized most rapidly and the oxidation rate decreases when longer diamines are tested. - Key Word Index - Lens esculenta; Leguminosae; lentil seedlings; copper protein; diamine oxidase.

Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers

A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six compounds demonstrated excellent inhibition activity against EGFRWT with the IC50 value both less than 2 nM. Among the six compounds, 44 exhibited the strongest activity (0.4 nM) and potently inhibited EGFRL858R/T790M (0.1 μM). Excitingly, the most potent compound 14 showed excellent enzyme inhibitory activity with 6.3 nM and 8.4 nM for both EGFRWT and EGFRT790M/L858R. The result of AO single staining and Annexin V/PI staining showed that the compound 14 and 44 could induce remarkable apoptosis of A549 cells. The compound 14 arrested the cell cycle at the S phase and compound 44 arrested the cell cycle at the G0 phase in A549 cells. These preliminary results demonstrate that compound 14 and 44 may be promising lead compound-targeting EGFR.

Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling

A series of water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes were designed and synthesized by using three complementary approaches aimed at introducing water-solubilizing groups on opposite faces of the fluorescent core to reduce or c