(Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

Base Information

Chemical Name:(Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine
CAS No.:1353883-42-7
Molecular Formula:C₁₆H₁₇BrF₂N₂
Molecular Weight:355.225
Hs Code.:

Synonyms:(Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

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Technology Process of (Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

There total 3 articles about (Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1353883-34-7
2-bromo-N-cyclohexyl-N'-(2-ethynylphenyl)-2,2-difluoroacetimidamide

: 1353883-42-7
(Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

Guidance literature:: With copper diacetate; In toluene; at 80 ℃; for 1h;
DOI:10.1039/c1ob06528a

Reference yield:

: 52670-38-9
2-ethynylaniline

: 1353883-42-7
(Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrachloromethane; triethylamine; triphenylphosphine / 80 °C

2: triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C

3: copper diacetate / toluene / 1 h / 80 °C

With tetrachloromethane; copper diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; toluene;
DOI:10.1039/c1ob06528a

Reference yield:

: 1353883-62-1
C₁₀H₅BrClF₂N

: 108-91-8,157973-60-9
cyclohexylamine

: 1353883-42-7
(Z)-N-(2-bromo-2,2-difluoro-1-(1H-indol-1-yl)ethylidene)-cyclohexanamine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C

2: copper diacetate / toluene / 1 h / 80 °C

With copper diacetate; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1039/c1ob06528a