(4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

Base Information

Chemical Name:(4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether
CAS No.:338385-68-5
Molecular Formula:C₂₆H₃₈O₄Si
Molecular Weight:442.671
Hs Code.:

Synonyms:(4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

Suppliers and Price of (4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

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Technology Process of (4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

There total 3 articles about (4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 338385-66-3
(4S)-4-hydroxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

: 338385-68-5
(4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(01)00050-3

Reference yield:

: 81801-09-4
4-O-benzyl-2,3-O-isopropylidene-D-threose

: 338385-68-5
(4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / tetrahydrofuran / -78 - 20 °C

2: 88 percent / imidazole / dimethylformamide / 24 h / 20 °C

With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Grignard reaction;
DOI:10.1016/S0040-4020(01)00050-3

Reference yield:

: phenylmagnesium bromide

: 338385-68-5
(4S)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / tetrahydrofuran / -78 - 20 °C

2: 88 percent / imidazole / dimethylformamide / 24 h / 20 °C

With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Grignard reaction;
DOI:10.1016/S0040-4020(01)00050-3