(2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester

Base Information

• Chemical Name: (2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester
• CAS No.: 623560-28-1
• Molecular Formula: C₁₄H₂₁O₅PS
• Molecular Weight: 332.358
• Mol file: 623560-28-1.mol

Synonyms:(2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester

Chemical Property of (2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester

There total 1 articles about (2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(bromomethyl)-3-(phenylsulfonyl)-1-propene (129800-98-2) + triethyl phosphite (122-52-1) → (2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester (623560-28-1)

Guidance literature:

at 140 ℃; for 3h;

DOI:10.1021/ja0377596

Reference yield:

tert-butyl glyoxylate (7633-32-1) + (2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester (623560-28-1) → (2E,4Z)-5-benzenesulfonyl-4-methylpenta-2,4-dienoic acid tert-butyl ester (623560-44-1) + (2E,4E)-5-benzenesulfonyl-4-methylpenta-2,4-dienoic acid tert-butyl ester (623560-43-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

DOI:10.1021/ja0377596

Reference yield:

(2-benzenesulfonylmethylallyl)phosphonic acid diethyl ester (623560-28-1) → (2E,4Z)-5-benzenesulfonyl-4-methylpenta-2,4-dienoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 5 h / 0 - 20 °C

2: TFA / tetrahydrofuran / 4 h / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/ja0377596

upstream raw materials:

2-(bromomethyl)-3-(phenylsulfonyl)-1-propene

triethyl phosphite

Downstream raw materials:

(2E,4Z)-5-benzenesulfonyl-4-methylpenta-2,4-dienoic acid tert-butyl ester

(2E,4E)-5-benzenesulfonyl-4-methylpenta-2,4-dienoic acid tert-butyl ester

(1E,3E)-2-methyl-4-phenylbuta-1,3-dien-1-yl phenyl sulfone