[(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

Base Information

Chemical Name:[(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene
CAS No.:188120-33-4
Molecular Formula:C₂₈H₅₂O₆SSi₂
Molecular Weight:572.954
Hs Code.:

Synonyms:[(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

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Chemical Property of [(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

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Technology Process of [(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

There total 8 articles about [(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 188120-30-1
(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

: 188120-33-4
[(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4039(97)00042-7

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 188120-33-4
[(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

2: 91 percent / 2,6-lutidine / tetrahydrofuran / Ambient temperature

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran;
DOI:10.1016/S0040-4039(97)00042-7

Reference yield:

: 112837-17-9
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

: 188120-33-4
[(Z)-(3R,4R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6,6-dimethoxy-3,4-dimethyl-hex-1-ene-1-sulfonyl]-benzene

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine

2: 1.) TMSCl; 2.) LiN(TMS)2, MeI / 1.) Et₂O, -78 deg C; 2.) THF, -78 deg C

3: Amberlyst 15 / methanol; H₂O / 80 °C

4: (COCl)2, DMSO, TEA / CH₂Cl₂

5: CSA / methanol

6: 85 percent / n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

7: 91 percent / 2,6-lutidine / tetrahydrofuran / Ambient temperature

With pyridine; 2,6-dimethylpyridine; n-butyllithium; chloro-trimethyl-silane; Amberlyst 15; oxalyl dichloride; TEA; camphor-10-sulfonic acid; dimethyl sulfoxide; lithium hexamethyldisilazane; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(97)00042-7