(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

Base Information

Chemical Name:(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane
CAS No.:188120-30-1
Molecular Formula:C₁₆H₂₄O₆S
Molecular Weight:344.429
Hs Code.:

Synonyms:(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

Suppliers and Price of (3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

Chemical Property:

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Technology Process of (3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

There total 7 articles about (3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 3112-85-4
methylphenylsulfonate

: 188120-28-7
(3R,4R,5R)-5-Dimethoxymethyl-3,4-dimethyl-dihydro-furan-2-one

: 188120-30-1
(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4039(97)00042-7

Reference yield: 85.0%

: 188120-30-1
(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

Guidance literature:

Reference yield:

: 112837-17-9
(R)-(+)-5-(hydroxymethyl)furan-2(5H)-one

: 188120-30-1
(3R,4R,5R)-2-Benzenesulfonylmethyl-5-dimethoxymethyl-3,4-dimethyl-2-hydroxyoxolane

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine

2: 1.) TMSCl; 2.) LiN(TMS)2, MeI / 1.) Et₂O, -78 deg C; 2.) THF, -78 deg C

3: Amberlyst 15 / methanol; H₂O / 80 °C

4: (COCl)2, DMSO, TEA / CH₂Cl₂

5: CSA / methanol

6: 85 percent / n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

With pyridine; n-butyllithium; chloro-trimethyl-silane; Amberlyst 15; oxalyl dichloride; TEA; camphor-10-sulfonic acid; dimethyl sulfoxide; lithium hexamethyldisilazane; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(97)00042-7