(S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Base Information

• Chemical Name: (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate
• CAS No.: 948842-94-2
• Molecular Formula: C₃₅H₃₉N₇O₈
• Molecular Weight: 685.737
• Mol file: 948842-94-2.mol

Synonyms:(S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Chemical Property of (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

There total 4 articles about (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

(S)-2-(benzyloxycarbonyl)propanoic acid silver salt + chloromethyl 5-(cyclopropylcarbamoyl)-2-methylphenyl(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamate (948842-91-9) → (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate (948842-94-2)

Guidance literature:

In toluene; for 9h; Heating / reflux;

Reference yield: 39.0%

chloromethyl 5-(cyclopropylcarbamoyl)-2-methylphenyl(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamate (948842-91-9) + silver salt of (S)-2-(benzyloxycarbonylamino)propanoic acid (948864-15-1) → (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate (948842-94-2)

Guidance literature:

In toluene; Reflux;

DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

BMS-582949 (623152-17-0) → (S)-((5-(cyclopropylcarbamoyl)-2-methylphenyl)(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate (948842-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 50 °C

2: toluene / Reflux

With pyridine; In dichloromethane; toluene;

DOI:10.1016/j.bmcl.2013.03.022

upstream raw materials:

chloromethyl 5-(cyclopropylcarbamoyl)-2-methylphenyl(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-yl)carbamate

BMS-582949

silver salt of (S)-2-(benzyloxycarbonylamino)propanoic acid

N-Cbz-Ala