4-chlorobenzoic acid [1,4]dioxan-2-yl ester

Base Information

• Chemical Name: 4-chlorobenzoic acid [1,4]dioxan-2-yl ester
• CAS No.: 1284251-42-8
• Molecular Formula: C₁₁H₁₁ClO₄
• Molecular Weight: 242.659
• Mol file: 1284251-42-8.mol

Synonyms:4-chlorobenzoic acid [1,4]dioxan-2-yl ester

Chemical Property of 4-chlorobenzoic acid [1,4]dioxan-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chlorobenzoic acid [1,4]dioxan-2-yl ester

There total 12 articles about 4-chlorobenzoic acid [1,4]dioxan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + para-chlorobenzoic acid (74-11-3) → 4-chlorobenzoic acid [1,4]dioxan-2-yl ester (1284251-42-8)

Guidance literature:

With tert.-butylhydroperoxide; tetrabutylammomium bromide; at 140 ℃; for 0.166667h; under 33753.4 Torr; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acs.joc.0c00519

Reference yield: 93.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 4-chlorophenylglyoxylic acid (7099-88-9) → 4-chlorobenzoic acid [1,4]dioxan-2-yl ester (1284251-42-8)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; at 80 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ob40748a

Reference yield: 83.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + tert-butyl p-chloroperoxybenzoate (2203-13-6) → 4-chlorobenzoic acid [1,4]dioxan-2-yl ester (1284251-42-8)

Guidance literature:

With copper-iron mixed oxide; In acetonitrile; at 140 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.joc.5b01043

upstream raw materials:

1,4-dioxane

para-chlorobenzoic acid

4-chlorobenzaldehyde

4-chlorophenylglyoxylic acid