santin

Base Information

• Chemical Name: santin
• CAS No.: 27782-63-4
• Molecular Formula: C18H16 O7
• Molecular Weight: 344.321
• Hs Code.: 2914509090
• Mol file: 27782-63-4.mol

Synonyms:Flavone,5,7-dihydroxy-3,4',6-trimethoxy- (8CI); 3-Methylbetuletol;5,7-Dihydroxy-3,4',6-trimethoxyflavone; 5,7-Dihydroxy-3,6,4'-trimethoxyflavone;6-Hydroxykaempferol 3,6,4'-trimethyl ether; Centauridin; Santin

Chemical Property of santin

Chemical Property:

• Vapor Pressure: 7.6E-15mmHg at 25°C
• Melting Point: 157-159 °C
• Boiling Point: 597°Cat760mmHg
• PKA: 6.31±0.40(Predicted)
• Flash Point: 219.9°C
• PSA: 98.36000
• Density: 1.45g/cm³
• LogP: 2.89700

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of santin

There total 2 articles about santin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

5,7,3'-trihydroxy-3,6,4',5'-tetramethoxyflavone (30250-30-7) → 5,7-Dihydroxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one (27782-63-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; dimethyl sulfate; In acetone; at 20 ℃; for 1h;

DOI:10.1016/j.bioorg.2018.10.034

Reference yield:

→ 5,7-Dihydroxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one (27782-63-4)

Guidance literature:

Reference yield:

5,7-Dihydroxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one (27782-63-4) + dimethyl sulfate (77-78-1) → 3,5,6,7,4'-pentamethoxyflavone (4472-73-5) + 5-hydroxy-3,4',6,7-tetramethoxyflavone (14787-34-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetone; at 20 ℃; for 1h; Overall yield = 92 %; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.01.012

upstream raw materials:

5,7,3'-trihydroxy-3,6,4',5'-tetramethoxyflavone

Downstream raw materials:

5,7-diacetoxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

3,5,6,7,4'-pentamethoxyflavone

5-hydroxy-3,4',6,7-tetramethoxyflavone

Refernces